PHYSICAL MAPPING, CLONING, AND IDENTIFICATION OF GENES WITHIN A 500-KB REGION CONTAINING BRCA1

被引：22

作者：

BROWN, MA

JONES, KA

NICOLAI, H

BONJARDIM, M

BLACK, D

MCFARLANE, R

DEJONG, P

QUIRK, JP

LEHRACH, H

SOLOMON, E

机构：

[1] IMPERIAL CANC RES FUND,GENOME ANAL LAB,LONDON WC2A 3PX,ENGLAND

[2] BEATSON INST CANC RES,GLASGOW G61 1BD,LANARK,SCOTLAND

[3] ROSWELL PK CANC INST,BUFFALO,NY

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 10期

关键词：

D O I：

10.1073/pnas.92.10.4362

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

BRCA1 is a breast/ovarian cancer susceptibility gene on human chromosome 17q21. We describe a complete and detailed physical map of a 500-kb region of genomic DNA containing the BRCA1 gene and the partial cloning in phage P1 artificial chromosomes. Approximately 70 exons were isolated from this region, 11 of which were components of the BRCA1 gene. Analysis of the other exons revealed a rho-related G protein and the interferon-induced leucine-zipper protein IFP-35.

引用

页码：4362 / 4366

页数：5

共 14 条

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