TUMOR-LOCALIZING ACTIVITY OF PORPHYRIN AND ITS AFFINITY TO LDL, TRANSFERRIN

被引：49

作者：

NAKAJIMA, S

TAKEMURA, T

SAKATA, I

机构：

[1] HOKKAIDO UNIV,ELECTR SCI RES INST,SAPPORO,HOKKAIDO 060,JAPAN

[2] TOYOHAKKA CO LTD,OKAYAMA 71903,JAPAN

来源：

CANCER LETTERS | 1995年 / 92卷 / 01期

关键词：

PORPHYRIN; TUMOR-LOCALIZING CAPACITY; GA-CN-P; 99M-TC-STA-R12; LDL; TRANSFERRIN;

D O I：

10.1016/0304-3835(95)03762-L

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We spectrochemically analyzed 12 Ga-Metal porphyrins (Ga-Cn-P) with different degrees of hydrophobicity, and observed a close association between the in vivo Ga-Cn-P localization in the tumor and its affinity to transferrin and LDL. Image analysis of tumors with 99m-Tc-STA-R12, a porphyrin-scintigraphic agent, revealed STA-R12 localization in the tumor tissue alone about 1 h after intravenous infusion. Our results suggest the importance of endocytosis mediated by transferrin as well as LDL that have been reported as a mechanism of the tumor-localizing activity of porphyrin.

引用

页码：113 / 118

页数：6

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