CONCENTRATION DEPENDENT PLASMA-PROTEIN BINDING OF SALICYLATE IN RHEUMATOID PATIENTS

被引：37

作者：

EKSTRAND, R

ALVAN, G

BORGA, O

机构：

[1] HUDDINGE HOSP,DEPT CLIN PHARMACOL,S-14186 HUDDINGE,SWEDEN

[2] KAROLINSKA INST,DEPT INTERNAL MED,S-10401 STOCKHOLM 60,SWEDEN

[3] KAROLINSKA INST,DEPT CLIN PHARMACOL,S-10401 STOCKHOLM 60,SWEDEN

来源：

CLINICAL PHARMACOKINETICS | 1979年 / 4卷 / 02期

关键词：

D O I：

10.2165/00003088-197904020-00006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Acetylsalicylic acid in daily doses from 3 to 6g was prescribed to 8 patients with rheumatoid arthritis. Various assessments of clinical effect, as well as steady-state plasma concentrations and degree of plasma protein binding, were determined at each dose. The unbound fraction of salicylate increased with the dose, resulting in very high free concentrations of drug in some patients. No statistically significant relationship between total or unbound plasma concentration and the measurements of clinical efficacy were obtained. The marked increase with the dose in unbound salicylate concentration is interpreted as the result of the saturable elimination known to occur for this drug. © 1979, Adis International. All rights reserved.

引用

页码：137 / 143

页数：7

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