NMDA ANTAGONIST INHIBITS RAPID TOLERANCE TO ETHANOL

被引：55

作者：

KHANNA, JM ^{[1
]}

WU, PH ^{[1
]}

WEINER, J ^{[1
]}

KALANT, H ^{[1
]}

机构：

[1] ADDICT RES FDN,TORONTO M5S 2S1,ONTARIO,CANADA

来源：

BRAIN RESEARCH BULLETIN | 1991年 / 26卷 / 04期

关键词：

NMDA ANTAGONIST; ETHANOL; RAPID TOLERANCE; TILT-PLANE; HYPOTHERMIA;

D O I：

10.1016/0361-9230(91)90109-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To test whether N-methyl-D-aspartate (NMDA) receptors have a role in the development of ethanol tolerance, (+)MK-801, an NMDA antagonist, and (-)MK-801, an inactive isomer, were tested in a rapid tolerance paradigm. Results showed that (+)MK-801 blocked the development of rapid tolerance to ethanol in the tilt-plane and hypothermia tests, while (-)MK-801 was ineffective. Neither drug changed the blood ethanol levels in the treated and untreated animals. These data suggest that the known role of NMDA receptors in long-term synaptic facilitation may underlie the effect of learning in the development of tolerance to the motor-impairing and hypothermic effects of ethanol.

引用

页码：643 / 645

页数：3