INOTROPIC INFLUENCE OF MACROCYCLIC POLYETHERS ON TRACHEAL SMOOTH-MUSCLE

被引：5

作者：

KOLBECK, RC

NEAVE, CL

AGUIRRE, A

NOSEK, TM

PANNELL, KH

机构：

[1] UNIV TEXAS,DEPT CHEM,EL PASO,TX 79968

[2] MED COLL GEORGIA,DEPT MED,BIOPHYS RES GRP,AUGUSTA,GA 30912

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 42卷 / 04期

关键词：

SMOOTH MUSCLE; TRACHEA; CROWN ETHER IONOPHORES; MEMBRANE PHYSIOLOGY;

D O I：

10.1016/0091-3057(92)90010-D

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Incubated guinea pig tracheal smooth muscle exhibited both positive and negative inotropic responses to a variety of crown ether analogs that ranged in size from 12-crown-4 to 30-crown-10 and included molecules whose lipophilicity was modified by the addition of benzo- and cyclohexo- substituents on the basic molecular framework. The inotropic influence of crown ethers may not only be due to their ionophoretic capabilities but may result from their ability to affect alterations in membrane physiology.

引用

页码：645 / 650

页数：6

共 32 条

[11]

GOLENHOFEN K, 1975, BLOOD VESSELS, V12, P21

[12] GUINEA-PIG TRACHEOBRONCHIAL SPIRAL STRIP - RESPONSES TO SELECTED AGONISTS [J].