THE MACROPHAGE-ACTIVATING TETRAPEPTIDE TUFTSIN INDUCES NITRIC-OXIDE SYNTHESIS AND STIMULATES MURINE MACROPHAGES TO KILL LEISHMANIA PARASITES IN-VITRO

被引：32

作者：

CILLARI, E ^{[1
]}

ARCOLEO, F ^{[1
]}

DIELI, M ^{[1
]}

DAGOSTINO, R ^{[1
]}

GROMO, G ^{[1
]}

LEONI, F ^{[1
]}

MILANO, S ^{[1
]}

机构：

[1] ITALFARMACO RES CTR, I-20092 CINISELLO BALSAMO, ITALY

来源：

INFECTION AND IMMUNITY | 1994年 / 62卷 / 06期

关键词：

D O I：

10.1128/IAI.62.6.2649-2652.1994

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The macrophage-activating tetrapeptide tuftsin was able to activate, in a dose-dependent manner, murine macrophages to express nitric oxide (NO) synthase and to produce NO. Tuftsin required lipopolysaccharides for the optimal induction of NO production and synergized with gamma interferon in the induction of NO synthesis. Tuftsin-dependent NO production was sensitive to inhibition by dexamethasone and the NO synthase specific inhibitor L(G)N-monomethylarginine (L-NMMA). Murine peritoneal macrophages activated by tuftsin were able to kill the amastigotes of the intracellular protozoan parasite Leishmania major in vitro.

引用

页码：2649 / 2652

页数：4