ENZYME-CATALYZED FORMATION OF CHIRAL MONOSUBSTITUTED MIXED DIESTERS AND HALF ESTERS OF MALONIC-ACID IN ORGANIC-SOLVENTS

被引：11

作者：

GUTMAN, AL

SHAPIRA, M

BOLTANSKI, A

机构：

[1] Department of Chemistry, Technion Israel Institute of Technology

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 04期

关键词：

D O I：

10.1021/jo00030a004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enzymes in organic solvents were used to develop a strategy for the formation of heretofore unknown chiral monosubstituted malonate diesters and half esters. This enzymatic approach is not feasible in aqueous solutions because the activated malonic hydrogen invariably undergoes fast exchange accompanied by racemization.

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页码：1063 / 1065

页数：3

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