SYNTHESIS AND NONTHROMBOGENICITY OF POLYMER MEMBRANE WITH SURFACE-GRAFT POLYMERS CARRYING THROMBIN INHIBITOR

被引：22

作者：

ITO, Y ^{[1
]}

LIU, LS ^{[1
]}

MATSUO, R ^{[1
]}

IMANISHI, Y ^{[1
]}

机构：

[1] KYOTO UNIV,DEPT POLYMER CHEM,YOSHIDA HONMACHI,SAKYO KU,KYOTO 606,JAPAN

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH | 1992年 / 26卷 / 08期

关键词：

D O I：

10.1002/jbm.820260808

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An acrylamide derivative of a thrombin inhibitor was synthesized and graft polymerized to the surfaces of polymer membranes. The thrombin-inhibitor activity was unaffected by the introduction of an acryloyl group. The surface-graft membrane deactivated thrombin markedly and suppressed adhesion of platelets, resulting in a high nonthrombogenicity. Immersion of polymer membranes blended with the thrombin inhibitor in phosphate-buffered saline for 10 d resulted in the loss of nonthrombogenicity, while the polymer membranes grafted with the thrombin inhibitor derivative maintained the nonthrombogenicity over a long period.

引用

页码：1065 / 1080

页数：16

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