SYNTHESIS OF PYRAZOLE ANALOGS OF ISOAPTAZEPINE

被引：4

作者：

MASSA, S ^{[1
]}

ARTICO, M ^{[1
]}

MAI, A ^{[1
]}

MANCUSO, A ^{[1
]}

CORELLI, F ^{[1
]}

机构：

[1] UNIV SIENA,DIPARTIMENTO FARM CHIM BIOL,I-53100 SIENA,ITALY

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1992年 / 29卷 / 07期

关键词：

D O I：

10.1002/jhet.5570290729

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the novel tetracyclic rings 5 and 6 is described starting from 4-cyano-1-methyl-5-(1H-pyrrol-1-yl)-1H-pyrazole and its 3-(1H-pyrrol-1-yl)- isomer, respectively. The pathway employed is based on a one-pot double annelation reaction involving the transformation of 13 into the required tetracyclic derivative 16. Lithium aluminum hydride/sulfuric acid reduction of the last compound furnished 5. A similar way was used for the synthesis of 6 by cyclization of 20.

引用

页码：1851 / 1854

页数：4

共 11 条

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