ROLE OF CYTOKINE-INDUCED NEUTROPHIL CHEMOATTRACTANT, A MEMBER OF THE INTERLEUKIN-8 FAMILY, IN RAT EXPERIMENTAL COLITIS

被引:32
作者
HARADA, K
TOYONAGA, A
MITSUYAMA, K
SASAKI, E
TANIKAWA, K
机构
[1] Second Department of Medicine, Kurume University School of Medicine, Kurume
关键词
TNB COLITIS; CYTOKINE-INDUCED NEUTROPHIL; CHEMOATTRACTANT; NEUTROPHIL; INTERLEUKIN-8; ULCERATIVE COLITIS; CROHNS DISEASE;
D O I
10.1159/000201145
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
A study was made of the role of cytokine-induced neutrophil chemoattractant (CINC), regarded as a member of the interleukin-8 family, in rat experimental colitis induced by trinitrobenzene sulfonic acid and ethanol. Colonic myeloperoxidase (MPO) activity, a marker of tissue neutrophil infiltration, was observed to reach a plateau from 24 h to 1 week following the induction of colitis; tissue CINC levels, as measured by enzyme-linked immunosorbent assay, rose rapidly, peaking at 12 h before the rise in myeloperoxidase activity. The time-course of tissue leukotriene B-4, another chemoattractant, was followed by that of MPO activity. Neutrophil accumulation into tissue in this model would thus appear to be under the control of CINC. Anti-CINC was also noted to inhibit 32.9 to 58.1% of chemotactic activity determined by bioassay during the same period, this being further evidence that CINC is a major chemotactic agent in this model. The present results indicate that CINC may have a crucial role in initiating neutrophil infiltration in experimental colitis.
引用
收藏
页码:179 / 184
页数:6
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