EXTENDED MONOD KINETICS FOR SUBSTRATE, PRODUCT, AND CELL-INHIBITION

被引:276
作者
HAN, K [1 ]
LEVENSPIEL, O [1 ]
机构
[1] OREGON STATE UNIV, DEPT CHEM ENGN, CORVALLIS, OR 97331 USA
关键词
Bacteriology - Biological Materials--Mathematical Models - Microorganisms;
D O I
10.1002/bit.260320404
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A generalized form of Monod kinetics is proposed to account for all kinds of product, cell, and substrate inhibition. This model assumes that there exists a critical inhibitor concentration above which cells cannot grow, and that the constants of the Monod equation are functions of this limiting inhibitor concentration. Methods for evaluating the constants of this rate form are presented. Finally, the proposed kinetic form is compared with the available data in the literature, which unfortunately is very sparse. In all cases, this equation form fitted the data very well.
引用
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页码:430 / 437
页数:8
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