SKELETAL-MUSCLE BETA-ADRENOCEPTOR DISTRIBUTION AND RESPONSES TO ISOPROTERENOL IN HYPERTHYROIDISM

被引:18
作者
MARTIN, WH [1 ]
KORTE, E [1 ]
TOLLEY, TK [1 ]
SAFFITZ, JE [1 ]
机构
[1] WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1992年 / 262卷 / 04期
关键词
AUTORADIOGRAPHY; INSULIN; LACTIC ACID; PERIPHERAL BLOOD FLOW; THYROTOXICOSIS;
D O I
10.1152/ajpendo.1992.262.4.E504
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
To determine whether hyperthyroidism selectively increases beta-adrenergic receptor density in vessels or fibers of human skeletal muscle, we characterized beta-receptor distribution autoradiographically in muscle biopsies of 18 subjects aged 26 +/- 1 yr before and after daily administration of 100-mu-g 3,5,3'-triiodothyronine (T3) for 2 wk. To establish whether vascular and metabolic responses to beta-adrenergic stimulation are concomitantly altered, we quantified calf blood flow and plasma concentrations of glucose, lactate, glycerol, free fatty acids (FFA), insulin, and C-peptide during graded-dose isoproterenol infusion in eight of these individuals. Differences in beta-adrenergic receptor density among muscle fiber types and vascular components were highly significant (type I > type IIa > type IIb muscle fibers, P < 0.001; and type I muscle fibers > resistance arterioles, P < 0.05). Hyperthyroidism increased beta-adrenergic receptor density in all types of muscle fibers (+31-50%; P < 0.01) but not in resistance arterioles. There was no change in calf blood flow or plasma glucose, glycerol, FFA, insulin, or C-peptide responses to isoproterenol. A rise in lactate during stages 3 and 4 of isoproterenol infusion (P < 0.01) was observed before but not after T3 administration. Thus hyperthyroidism increases beta-adrenergic receptor density in fibers but not vessels of human skeletal muscle without increasing either metabolic or vascular responses to selective beta-adrenergic stimulation.
引用
收藏
页码:E504 / E510
页数:7
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