TRANSFORMING GROWTH-FACTOR-BETA INDUCES MYOBLAST DIFFERENTIATION IN THE PRESENCE OF MITOGENS

被引：94

作者：

ZENTELLA, A ^{[1
]}

MASSAGUE, J ^{[1
]}

机构：

[1] MEM SLOAN KETTERING CANC CTR,HOWARD HUGHES MED INST,NEW YORK,NY 10021

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 11期

关键词：

GROWTH INHIBITION; MYOGENESIS; CELL CYCLE;

D O I：

10.1073/pnas.89.11.5176

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transforming growth factor beta-1 (TGF-beta-1) added to L6E9 rat skeletal myoblasts in mitogen-rich medium induces a rapid decrease in c-myc expression and delays progression through the G1 phase of the cell cycle. This growth inhibitory response is followed by cell commitment to terminal differentiation with elevated expression of myogenin muscle determination genes, induction of muscle-specific proteins, and formation of multinucleated myotubes. These results suggest that TGF-beta-1 may act as a physiological inducer of myogenic differentiation in mitogen-rich environments, and its otherwise reversible growth inhibitory effect may become permanent if coupled to induction of terminal differentiation.

引用

页码：5176 / 5180

页数：5

共 54 条

[1]

AKHURST RJ, 1990, DEVELOPMENT, V108, P645

[2] FUNCTIONAL-ROLE FOR C-MYC IN MITOGENIC RESPONSE TO PLATELET-DERIVED GROWTH-FACTOR [J].

ARMELIN, HA ;

ARMELIN, MCS ;

KELLY, K ;

STEWART, T ;

LEDER, P ;

COCHRAN, BH ;

STILES, CD .

NATURE, 1984, 310 (5979) :655-660

[3] IMMUNOCHEMICAL ANALYSIS OF MYOSIN HEAVY-CHAIN DURING AVIAN MYOGENESIS INVIVO AND INVITRO [J].

BADER, D ;

MASAKI, T ;

FISCHMAN, DA .

JOURNAL OF CELL BIOLOGY, 1982, 95 (03) :763-770

[4] THE RETINOBLASTOMA PROTEIN COPURIFIES WITH E2F-I, AN E1A-REGULATED INHIBITOR OF THE TRANSCRIPTION FACTOR E2F [J].

BAGCHI, S ;

WEINMANN, R ;

RAYCHAUDHURI, P .

CELL, 1991, 65 (06) :1063-1072

[5] THE PROTEIN ID - A NEGATIVE REGULATOR OF HELIX-LOOP-HELIX DNA-BINDING PROTEINS [J].

BENEZRA, R ;

DAVIS, RL ;

LOCKSHON, D ;

TURNER, DL ;

WEINTRAUB, H .

CELL, 1990, 61 (01) :49-59

[6]

BLAU HM, 1991, J CELL BIOL, V112, P581

[7] TRANSFORMING GROWTH-FACTOR-BETA REPRESSES THE ACTIONS OF MYOGENIN THROUGH A MECHANISM INDEPENDENT OF DNA-BINDING [J].

BRENNAN, TJ ;

EDMONDSON, DG ;

LI, L ;

OLSON, EN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :3822-3826

[8] IDENTIFICATION OF A MYOCYTE NUCLEAR FACTOR THAT BINDS TO THE MUSCLE-SPECIFIC ENHANCER OF THE MOUSE MUSCLE CREATINE-KINASE GENE [J].

BUSKIN, JN ;

HAUSCHKA, SD .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (06) :2627-2640

[9] THE E2F TRANSCRIPTION FACTOR IS A CELLULAR TARGET FOR THE RB PROTEIN [J].

CHELLAPPAN, SP ;

HIEBERT, S ;

MUDRYJ, M ;

HOROWITZ, JM ;

NEVINS, JR .

CELL, 1991, 65 (06) :1053-1061

[10] THE T/E1A-BINDING DOMAIN OF THE RETINOBLASTOMA PRODUCT CAN INTERACT SELECTIVELY WITH A SEQUENCE-SPECIFIC DNA-BINDING PROTEIN [J].

CHITTENDEN, T ;

LIVINGSTON, DM ;

KAELIN, WG .

CELL, 1991, 65 (06) :1073-1082

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