NMR ANALYSIS OF LOW-DENSITY-LIPOPROTEIN OXIDATIVELY-MODIFIED INVITRO

被引：18

作者：

BARENGHI, L

BRADAMANTE, S

GIUDICI, GA

VERGANI, C

机构：

[1] UNIV MILAN,IST MED INTERNA,VIA PACE 9,I-20122 MILAN,ITALY

[2] FDN RIVETTI,BIOCHIM & BIOL MOLEC LAB,MILAN,ITALY

[3] UNIV MILAN,CNR,CTR STUDIO SINTESI & STEREOCHIM SPECIALI SISTEMI ORGAN,I-20122 MILAN,ITALY

来源：

FREE RADICAL RESEARCH COMMUNICATIONS | 1990年 / 8卷 / 03期

关键词：

Ageing; Atherosclerosis; Lipid peroxidation; NMR spectroscopy; Oxidatively-modified LDL;

D O I：

10.3109/10715769009087991

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human plasma low density lipoprotein has been oxidized at different stages in vitro and analysed by 1H. 13C, and 31P NMR spectroscopy and by biochemical methods. Information was obtained on: a) structure mobilities of lipids and on lipid-protein interactions: b) conjugated and oxo-dienes; c) polyunsaturated/ monounsaturated fatty acid chains; d) lysophosphatidylcholine production. The results show that the NMR approach is particularly useful for the assessment of structural modification in oxidized LDL. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：175 / 183

页数：9

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