ELECTROPHYSIOLOGY OF THE INNER MITOCHONDRIAL-MEMBRANE

被引：133

作者：

ZORATTI, M

SZABO, I

机构：

[1] CNR Unit for the Physiology of Mitochondria, Department of Biomedical Sciences, University of Padova, Padova

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1994年 / 26卷 / 05期

关键词：

ION CHANNELS; PATCH-CLAMP; MITOCHONDRIAL MEGACHANNEL; PERMEABILITY TRANSITION; MITOCHONDRIA;

D O I：

10.1007/BF00762739

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The application of electrophysiological techniques to mitochondrial membranes has allowed the observation and partial characterization of several ion channels, including an ATP-sensitive K+-selective one, a high-conductance ''megachannel'', a 107 pS anionic channel and three others studied at alkaline pH's. A reliable correlation with the results of non-electrophysiological studies has been obtained so far only for the first two cases. Activities presumed to be associated with the Ca2+ uniporter and with the adenine nucleotide translocator, as well as the presence of various other conductances have also been reported. The review summarizes the main properties of these pores and their possible relationship to permeation pathways identified in biochemical studies.

引用

页码：543 / 553

页数：11

共 111 条

[1]

ALEXANDER BEE, 1993, PHARMAZIE, V48, P563

[2] SELECTIVE EFFECT OF INHIBITORS ON INNER MITOCHONDRIAL-MEMBRANE CHANNELS [J].

ANTONENKO, YN ;

KINNALLY, KW ;

PERINI, S ;

TEDESCHI, H .

FEBS LETTERS, 1991, 285 (01) :89-93

[3] IDENTIFICATION OF ANION AND CATION PATHWAYS IN THE INNER MITOCHONDRIAL-MEMBRANE BY PATCH CLAMPING OF MOUSE-LIVER MITOPLASTS [J].

ANTONENKO, YN ;

KINNALLY, KW ;

TEDESCHI, H .

JOURNAL OF MEMBRANE BIOLOGY, 1991, 124 (02) :151-158

[4]

BEAVIS AD, 1987, J BIOL CHEM, V262, P15085

[5]

BEAVIS AD, 1988, J BIOL CHEM, V263, P7574

[6]

BEAVIS AD, 1989, J BIOL CHEM, V264, P17148

[7]

BEAVIS AD, 1993, J BIOL CHEM, V268, P997

[8] PROPERTIES OF THE INNER MEMBRANE ANION CHANNEL IN INTACT MITOCHONDRIA [J].

BEAVIS, AD .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1992, 24 (01) :77-90

[9]

BEAVIS AD, 1989, J BIOL CHEM, V264, P1508

[10] RECENT PROGRESS ON REGULATION OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE - A CYCLOSPORINE-SENSITIVE PORE IN THE INNER MITOCHONDRIAL-MEMBRANE [J].

BERNARDI, P ;

BROEKEMEIER, KM ;

PFEIFFER, DR .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1994, 26 (05) :509-517

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