ELECTROPHYSIOLOGY OF THE INNER MITOCHONDRIAL-MEMBRANE

被引：133

作者：

ZORATTI, M

SZABO, I

机构：

[1] CNR Unit for the Physiology of Mitochondria, Department of Biomedical Sciences, University of Padova, Padova

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1994年 / 26卷 / 05期

关键词：

ION CHANNELS; PATCH-CLAMP; MITOCHONDRIAL MEGACHANNEL; PERMEABILITY TRANSITION; MITOCHONDRIA;

D O I：

10.1007/BF00762739

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The application of electrophysiological techniques to mitochondrial membranes has allowed the observation and partial characterization of several ion channels, including an ATP-sensitive K+-selective one, a high-conductance ''megachannel'', a 107 pS anionic channel and three others studied at alkaline pH's. A reliable correlation with the results of non-electrophysiological studies has been obtained so far only for the first two cases. Activities presumed to be associated with the Ca2+ uniporter and with the adenine nucleotide translocator, as well as the presence of various other conductances have also been reported. The review summarizes the main properties of these pores and their possible relationship to permeation pathways identified in biochemical studies.

引用

页码：543 / 553

页数：11

共 111 条

[51] MITOCHONDRIAL BENZODIAZEPINE RECEPTOR LINKED TO INNER MEMBRANE ION CHANNELS BY NANOMOLAR ACTIONS OF LIGANDS [J].

KINNALLY, KW ;

ZOROV, DB ;

ANTONENKO, YN ;

SNYDER, SH ;

MCENERY, MW ;

TEDESCHI, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (04) :1374-1378

[52] CALCIUM MODULATION OF MITOCHONDRIAL INNER MEMBRANE CHANNEL ACTIVITY [J].

KINNALLY, KW ;

ZOROV, D ;

ANTONENKO, Y ;

PERINI, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 176 (03) :1183-1188

[53] MEMBRANE-PROTEIN OLIGOMERIC STRUCTURE AND TRANSPORT FUNCTION [J].

KLINGENBERG, M .

NATURE, 1981, 290 (5806) :449-454

[54] DIALECTICS IN CARRIER RESEARCH - THE ADP/ATP CARRIER AND THE UNCOUPLING PROTEIN [J].

KLINGENBERG, M .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1993, 25 (05) :447-457

[55] MECHANISM AND EVOLUTION OF THE UNCOUPLING PROTEIN OF BROWN ADIPOSE-TISSUE [J].

KLINGENBERG, M .

TRENDS IN BIOCHEMICAL SCIENCES, 1990, 15 (03) :108-112

[56] INNER MITOCHONDRIAL-MEMBRANE ANION CHANNEL IS PRESENT IN BROWN ADIPOCYTES BUT IS NOT IDENTICAL WITH THE UNCOUPLING PROTEIN [J].

KLITSCH, T ;

SIEMEN, D .

JOURNAL OF MEMBRANE BIOLOGY, 1991, 122 (01) :69-75

[57] CROSS-LINKING ANALYSIS OF YEAST MITOCHONDRIAL OUTER-MEMBRANE [J].

KRAUSE, J ;

HAY, R ;

KOWOLLIK, C ;

BRDICZKA, D .

BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 860 (03) :690-698

[58] SELECTIVITY FOR OMEGA-RECEPTOR SUBTYPES AS A STRATEGY FOR THE DEVELOPMENT OF ANXIOLYTIC DRUGS [J].

LANGER, SZ ;

ARBILLA, S ;

TAN, S ;

LLOYD, KG ;

GEORGE, P ;

ALLEN, J ;

WICK, AE .

PHARMACOPSYCHIATRY, 1990, 23 :103-107

[59]

LEQUOC K, 1985, J BIOL CHEM, V260, P7422

[60] THE INS AND OUTS OF MITOCHONDRIAL-MEMBRANE CHANNELS [J].

MANNELLA, CA .

TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (08) :315-320

← 1 2 3 4 5 6 7 8 9 10 →