EFFECT OF DL-ETHIONINE ON THE BIOSYNTHESIS OF ANTHRACYCLINES IN STREPTOMYCES-COERULEORUBIDUS

被引：6

作者：

BLUMAUEROVA, M

JIZBA, J

STAJNER, K

VANEK, Z

机构：

[1] Department of Biogenesis of Natural Substances, Institute of Microbiology, Czechoslovak Academy of Sciences, Prague 4 - Krč

来源：

BIOTECHNOLOGY LETTERS | 1979年 / 1卷 / 11期

关键词：

D O I：

10.1007/BF01388429

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Inhibitory action of DL-ethionine on 4-0-methylation and 10-COOH-esterification of the anthracyclinone ring in Streptomyces coeruleorubidus causes the formation of substances of the carminomycinone series, a concomitant drop in the production of daunomycinone derivatives and suppression of the biosynthesis of ε-rhodomycinone. The extent of inhibition depends on inhibitor concentration and the time of its addition to cultures. Ho formation of anthracyclinone ethyl-derivatives was found. © 1979 Kluwer Academic Publishers.

引用

页码：471 / 476

页数：6

共 10 条

[1]

ARGOUDEL.AD, 1970, J ANTIBIOT, V23, P1

[2] IMPROVED YIELDS OF DAUNOMYCINONE GLYCOSIDES IN DEVELOPMENTAL MUTANTS OF STREPTOMYCES-COERULEORUBIDUS [J].

BLUMAUEROVA, M ;

POKORNY, V ;

STASTNA, J ;

HOSTALEK, Z ;

VANEK, Z .

FOLIA MICROBIOLOGICA, 1978, 23 (04) :249-+

[3] PHYSICAL AND CHEMICAL CHARACTERISTICS AND STRUCTURE OF CARMINOMYCIN, A NEW ANTITUMOR ANTIBIOTIC [J].

BRAZHNIKOVA, MG ;

ZBARSKY, VB ;

PONOMARENKO, VI ;

POTAPOVA, NP .

JOURNAL OF ANTIBIOTICS, 1974, 27 (04) :254-259

[4]

CASINELLI G, 1978, J ANTIBIOT, V31, P178

[5]

FLORENT J, 1976, Patent No. 2610557

[6]

GAUSE GF, 1974, CANCER CHEMOTH REP 1, V58, P255

[7]

JIZBA J, 1980, COLLECT CZECH CHEM C, V45

[8] PROPIONATE PRECURSORS IN THE BIOSYNTHESIS OF DAUNOMYCIN AND ADRIAMYCIN - C-13 NUCLEAR MAGNETIC-RESONANCE STUDY [J].

SHAW, GJ ;

MILNE, GWA ;

MINGHETTI, A .

PHYTOCHEMISTRY, 1979, 18 (01) :178-179

[9]

Vanek Z, 1973, Pure Appl Chem, V34, P463, DOI 10.1351/pac197334030463

[10]

VANEK Z, 1980, LLOYDIA, V43

← 1 →