SYNTHESIS AND ANTITUMOR EVALUATION OF WATER-SOLUBLE TAXOL PHOSPHATES

被引：77

作者：

VYAS, DM

WONG, H

CROSSWELL, AR

CASAZZA, AM

KNIPE, JO

MAMBER, SW

DOYLE, TW

机构：

[1] Bristol-Myers Squibb Company, Wallingford, CT 06492

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80348-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis and in vivo antitumor evaluation of water soluble 2'- and 7- taxol phosphates is reported. These derivatives were found to be poor prodrugs of taxol based on their marginal in vivo antitumor activity against ip,ip M109 murine tumor model and taxol release studies in vitro.

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页码：1357 / 1360

页数：4

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