ENANTIOSELECTIVE SYNTHESIS OF 1-METALLOCENYLALKANOLS BY CATALYTIC ASYMMETRIC ALKYLATION OF METALLOCENECARBOXALDEHYDES WITH DIALKYLZINCS

被引：56

作者：

MATSUMOTO, Y

OHNO, A

LU, SJ

HAYASHI, T

OGUNI, N

HAYASHI, M

机构：

[1] HOKKAIDO UNIV,CATALYSIS RES CTR,SAPPORO,HOKKAIDO 060,JAPAN

[2] HOKKAIDO UNIV,GRAD SCH PHARMACEUT SCI,SAPPORO,HOKKAIDO 060,JAPAN

[3] YAMAGUCHI UNIV,FAC SCI,DEPT CHEM,YAMAGUCHI 753,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(00)80411-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reaction of ferrocenecarboxaldehyde and ruthenocenecarboxaldehyde with diethylzinc or dimethylzinc in the presence of 5 mol % of (R)-3,3-dimethyl-1-piperidino-2-butanol proceeded with high enantioselectivity to give (R)-1-ferrocenylpropanol (>96% ee), (R)-1-ferrocenylethanol (>99% ee), (R)-1-ruthenocenylpropanol (96% ee), and (R)-1-ruthenocenylethanol (90% ee) in over 84% yield. The (R)-1-metallocenylalkanols were converted into the corresponding (R)-1-metallocenyl-N,N-dimethylamines.

引用

页码：1763 / 1766

页数：4

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