TARGETING OF RETROVIRAL VECTORS FOR GENE-THERAPY

被引:134
作者
SALMONS, B
GUNZBURG, WH
机构
[1] GSF FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT GMBH, INST MOLEK VIROL, W-8042 NEUHERBERG, GERMANY
[2] LUDWIG MAXIMILIANS UNIV, LEHRSTUHL MOLEK TIERZUCHT, W-8000 MUNICH, GERMANY
关键词
D O I
10.1089/hum.1993.4.2-129
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Retroviral vectors are one of the most promising vehicles for the delivery of therapeutic genes in human gene therapy protocols. Retroviral-mediated gene transfer currently being used in human clinical trials is based upon ex vivo transduction of target cells. The ability to target the delivery and expression of therapeutic genes in vivo using retroviral vectors is a prerequisite for widespread and routine use in the clinic and will be of great importance for the safe and successful treatment of certain genetic disorders as well as tumors and viral infections. A number of approaches have been taken to develop retroviral vectors that are able to target particular cell types both at the level of the transduction event and at the level of expression. Using various combinations of the restrictive features reviewed in this article, it should be possible to achieve definitive targeting of genes transduced by retroviral vectors.
引用
收藏
页码:129 / 141
页数:13
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