METABOLISM OF S-[(2-METHOXY-5-OXO-DELTA2-1,3,4-THIADIAZOLIN-4-YL)METHYL]-O,O-DIMETHYL PHOSPHORODITHIOATE (SUPRACIDE) IN ALFALFA

Metabolic studies of alfalfa treated with C14-S-[(2-methoxy-5-oxo-∆2-1,3,4-thiadiazolin-4-yl)methyl]-O,O-dimethyl phosphorodithioate (Supracide) are described. Though the cholinesteraseinhibiting oxygen analog is present, it is not the major route of metabolism. It decreases steadily after treatment. Water-soluble C14 residues are not cholinesterase-inhibiting. One of these, based on thin-layer chromatographic Rf values, appears to be a labile conjugate which, upon standing, hydrolyzes to the desmethyl compound. The majority of the water-soluble radioactivity is polar, and based on Rf's, the same pattern is found whether the ring- or methoxy-labeled pesticide is used. Fragmentation of methoxy- or ring-labeled parent compound is suggested by C14O2 release to the atmosphere or incorporation into the carbon pool of a plant. © 1969, American Chemical Society. All rights reserved.