FATE OF S-[(2-METHOXY-5-OXO-DELTA2-1,3,4-THIADIAZOLIN-4-YL)METHYL]O,O-DIMETHYL PHOSPHORODITHIOATE (SUPRACIDE) IN A LACTATING COW

A cow was fed C14-labeled S-[(2-methoxy-5-oxo-∆2-1,3,4-thiadiazolin-4-yl) methyl] O,O-dimethyl phosphorodithioate (Supracide) for 5 days at the rate of 1 mg. per kg. per day. No Supracide or its oxygen analog was found in the milk. The sensitivity of the analytical procedures was 0.01 p.p.m. for each compound. The total amount of radioactivity found in the milk during the 15-day study represented only 0.6% of the oral dosage. Fractionation of the milk indicated extensive metabolism, as did the nature of the radioactivity recovered in the urine (24%) and feces (34%). Total radioactivity determined in tissues indicates that significant storage does not occur. The highest level of radioactivity found in tissues was 0.11 p.p.m. in the liver. © 1969, American Chemical Society. All rights reserved.