ACUTE TOXICITY OF ORAL DIQUAT (1,1'-ETHYLENE-2,2'-BIPYRIDINIUM) IN CYNOMOLGUS MONKEYS

被引：10

作者：

COBB, LM ^{[1
]}

GRIMSHAW, P ^{[1
]}

机构：

[1] HUNTINGDON RES CTR, DEPT ENVIRONM PHYSIOL, HUNTINGDON PE18 6ES, ENGLAND

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 1979年 / 51卷 / 02期

关键词：

D O I：

10.1016/0041-008X(79)90470-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Single doses of 100, 200, 300, and 400 mg diquat [herbicide] ion/kg body wt were administered by stomach tube to cynomolgus monkeys. Within 4 days of dosing, deaths occurred in 1/2, 0/4, 1/2, and 2/2 monkeys, respectively. All animals developed diarrhea and the most severely affected became comatose. The most important histopathological changes were necrosis of the epithelium and villi of the gastrointestinal tract, and the epithelium of the proximal and distal convoluted tubules of the kidneys.

引用

页码：277 / 282

页数：6