IMPROVEMENT OF THE DIURETIC EFFECT OF TRIAMTERENE VIA SOLID DISPERSION TECHNIQUE WITH PEG-4000

被引：6

作者：

ARIAS, MJ

GINES, JM

MOYANO, JR

PEREZBARRALES, MJ

VELA, MT

RABASCO, AM

机构：

[1] Departamento de Farmacia y Tecnologia Farmaceutica, Catedra de Farmacia Galenica, Facultad de Farmacia, Universidad de Sevilla, Sevilla, 41012, C/ Profesor García González s/n

来源：

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS | 1994年 / 19卷 / 04期

关键词：

TRIAMTERENE; PEG; 4000; SOLID DISPERSION; ABSORPTION; DIURETIC EFFECT;

D O I：

10.1007/BF03188855

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present investigation was designed and undertaken in order to substantiate further contention concerning the universality of the utilization of PEG polymers as matrix carriers. This study could then be considered an attempt to enhance the dissolution rate of triamterene, with the subsequent enhancement in its absorption rate, via solid dispersion using PEG 4000. The approach of solid dispersions was found useful for optimizing the pharmacokinetic of triamterene in rats.

引用

页码：295 / 302

页数：8

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