INVIVO RELAXOMETRY OF 3 BRAIN-TUMORS IN THE RAT - EFFECT OF MN-TPPS, A TUMOR-SELECTIVE CONTRAST AGENT

被引：23

作者：

WILMES, LJ ^{[1
]}

HOEHNBERLAGE, M ^{[1
]}

ELS, T ^{[1
]}

BOCKHORST, K ^{[1
]}

EIS, M ^{[1
]}

BONNEKOH, P ^{[1
]}

HOSSMANN, KA ^{[1
]}

机构：

[1] MAX PLANCK INST NEUROL RES,EXPTL NEUROL ABT,GLEULERSTR 50,W-5000 COLOGNE 41,GERMANY

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1993年 / 3卷 / 01期

关键词：

BRAIN NEOPLASMS; MR; CONTRAST ENHANCEMENT; CONTRAST MEDIA; MANGANESE; RELAXOMETRY; TISSUE CHARACTERIZATION;

D O I：

10.1002/jmri.1880030103

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

T1 and T2 were determined simultaneously in vivo at 4.7 T in implanted rat brain tumors. Three different tumor cell lines were implanted in the right caudate nucleus: the F98 glioma, the E367 neuroblastoma, and the RN6 schwannoma. Their T1 and T2 values (mean +/- standard deviation [msec]), respectively, were 1,312 +/- 107 and 89 +/- 3 (glioma), 1,284 +/- 86 and 87 +/- 7 (neuroblastoma), and 1,338 +/- 85 and 86 +/- 9 (schwannoma). The T1 values (msec) of normal brain and muscle were 1,090 +/- 59 and 1,139 +/- 77, respectively, and the T2 values (msec) were 76 +/- 3 and 36 +/- 2, respectively. After injection of the contrast agent manganese (III) tetraphenylporphine sulfonate (TPPS) the T1 of all three tumors decreased by 30% and the T2 by 10%, whereas no such change in relaxivity was noted in normal brain. As a result, strong contrast enhancement of the three tumor types was seen on T1-weighted images. The tumor was clearly delineated and correlated with findings at histologic examination. This tumor enhancement was followed up for 4 days with quantitative relaxation time measurements, and the strong, selective reduction in T1 for all three tumor types after Mn-TPPS injection was preserved over the entire observation period.

引用

页码：5 / 12

页数：8

共 36 条

[11]

Megnin F, Faustino PJ, Lyon RC, Lelkes PI, Cohen JS, Studies on the mechanism of selective retention of porphy‐rins and metalloporphyrins by cancer cells, Biochim Bio‐phys Acta, 929, pp. 173-181, (1987)

[12]

Fiel RJ, Mark E, Button T, Gillani S, Musser D, Mechanism of the localization of manganese (III) mesotetra(4‐sul‐fonatophenyl) Iporphine in mice bearing L1210 tumors, Cancer Lett, 40, pp. 23-32, (1988)

[13]

Bockhorst K, Hoehn-Berlage M, Kocher M, Hossmann K-A, Proton relaxation enhancement in experimental brain tumors: in vivo NMR study of manganese (III) TPPS in rat brain gliomas, Magn Reson Imaging, 8, pp. 499-504, (1990)

[14]

Ernestus R-I, Hoehn-Berlage M, Bockhorst K, Kloiber O., Hossmann K-A., Differentiation of tumor and edema in experimental tumors of the cat brain: application of the tumor‐specific NMR contrast agent manganese (III) tetra‐ phenylporphine sulfonate (abstr), Book of abstracts: Society of Magnetic Resonance in Medicine 1990, (1990)

[15]

Bockhorst K, (1991)

[16]

Hoehn-Berlage M, Norris D, Bockhorst K, Et al., T1 snapshot FLASH measurement of rat brain glioma: kinetics of the tumor‐enhancing contrast agent manganese (III) tetra‐phenylporphine sulfonate, Magnetic Resonance in Medicine, 27, pp. 201-213, (1992)

[17]

Hossmann K-A, Hurter T, Oschlies U, The effect of dexa‐methasone on serum protein extravasation and edema development in experimental brain tumors of cat, Acta Neuro‐pathol (Berlin), 60, pp. 223-231, (1983)

[18]

Lyon RC, Faustino PJ, Cohen JS, Et al., Tissue distribution and stability of metaloporphyrin MRI contrast agents, Magn Reson Med, 4, pp. 24-33, (1987)

[19]

Eis M, Hoehn-Berlage M, Bockhorst K, Hossmann K-A, A time efficient method for combined T1/T2 relaxation time measurements, evaluation for multi‐parameter tissue characterization (abstr), Book of abstracts: Society of Magnetic Resonance in Medicine 1991, (1991)

[20]

Eis M, (1989)

← 1 2 3 4 →