METABOLIC AND THERAPEUTIC EFFECTS OF INSULIN-LIKE GROWTH-FACTOR-I

被引：30

作者：

FROESCH, ER

ZENOBI, PD

HUSSAIN, M

机构：

[1] Division of Endocrinology and Metabolism, Department of Medicine, University of Zurich

来源：

HORMONE RESEARCH | 1994年 / 42卷 / 1-2期

关键词：

RHIGF-I THERAPY; INSULIN INHIBITION; GROWTH HORMONE INHIBITION; INSULIN SENSITIVITY; LIPID METABOLISM;

D O I：

10.1159/000184148

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The administration of rhIGF-I in appropriate doses leads to a decrease of insulin and growth hormone secretion and to an increase of insulin sensitivity. In type 2 diabetic patients, IGF-I improves glycemic profiles. In normal subjects, IGF-I increases energy expenditure and lipid oxidation and has a protein-sparing effect. Total and VLDL-triglycerides as well as LDL-cholesterol are decreased by IGF-I administration. This metabolic profile of IGF-I allows speculation on its possible usefulness in conditions of relative insulin resistance often associated with increased cardiovascular morbidity and mortality.

引用

页码：66 / 71

页数：6