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ROLE OF CELLULAR REDOX STATE AND GLUTATHIONE IN ADENYLATE-CYCLASE ACTIVITY IN RAT ADIPOCYTES
被引:39
作者
:
MUKHERJEE, SP
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
MUKHERJEE, SP
[
1
]
LYNN, WS
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
LYNN, WS
[
1
]
机构
:
[1]
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
来源
:
BIOCHIMICA ET BIOPHYSICA ACTA
|
1979年
/ 568卷
/ 01期
基金
:
美国国家卫生研究院;
关键词
:
(Adipocyte);
Adenylate cyclase;
Glutathione;
Redox state;
Sulfhydryl group;
D O I
:
10.1016/0005-2744(79)90289-4
中图分类号
:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号
:
071010 ;
081704 ;
摘要
:
Adenylate cyclase in rat adipocyte membranes was inactivated as a result of treatment with sulfhydryl oxidants or with p-chloromercuribenzoate as well as by S-alkylating agents. The inhibition of the basal and isoproterenol- or glucagon-stimulated enzyme activity by the oxidants or the mercurial could be reversed by adding thiols to the isolated membranes. The activity of the enzyme paralleled the cellular glutathione (GSH) content. Lowering of intracellular glutathione by incubatng the cells with specific reactants resulted in the inhibition of both basal and hormone-stimulated adenylate cyclase activity in the isolated membranes. Activity could be partly restored by supplying glucose to the incubation medium of intact cells. The fluoride-stimulated adenylate cyclase was also inhibited by the oxidants or the sulfhydryl inhibitors. The results suggest that adenylate cyclase may be partialy regulated by oxidation-reduction. Thus, a direct relationship between both basal and hormone-stimulated adenylate cyclase activity and the cellular redox potential, determined by the cellular level of reduced glutathione, may be ascribed to the protection of the catalytic -SH groups of the enzyme from oxidative or peroxidative reactions and maintenance of the redox optimum for the reaction. © 1979.
引用
收藏
页码:224 / 233
页数:10
相关论文
共 38 条
[21]
CATECHOLAMINE-INDUCED SUBSENSITIVITY OF ADENYLATE CYCLASE ASSOCIATED WITH LOSS OF BETA-ADRENERGIC-RECEPTOR BINDING-SITES
MUKHERJEE, C
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT BIOCHEM,DURHAM,NC
MUKHERJEE, C
CARON, MG
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT BIOCHEM,DURHAM,NC
CARON, MG
LEFKOWITZ, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT BIOCHEM,DURHAM,NC
LEFKOWITZ, RJ
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1975,
72
(05)
: 1945
-
1949
[22]
MUKHERJEE SP, 1978, FED PROC, V37, P1689
[23]
MUKHERJEE SP, 1976, FED PROC, V35, P1694
[24]
REDUCED NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE OXIDASE IN ADIPOCYTE PLASMA-MEMBRANE AND ITS ACTIVATION BY INSULIN - POSSIBLE ROLE IN HORMONES EFFECTS ON ADENYLATE-CYCLASE AND HEXOSE MONOPHOSPHATE SHUNT
MUKHERJEE, SP
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT BIOCHEM,DURHAM,NC 27710
MUKHERJEE, SP
LYNN, WS
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT BIOCHEM,DURHAM,NC 27710
LYNN, WS
[J].
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,
1977,
184
(01)
: 69
-
76
[25]
ENDOGENOUS HYDROGEN-PEROXIDE AND PEROXIDATIVE METABOLISM IN ADIPOCYTES IN RESPONSE TO INSULIN AND SULFHYDRYL-REAGENTS
MUKHERJEE, SP
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
MUKHERJEE, SP
LANE, RH
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
LANE, RH
LYNN, WS
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
LYNN, WS
[J].
BIOCHEMICAL PHARMACOLOGY,
1978,
27
(22)
: 2589
-
2594
[26]
EFFECT OF EPINEPHRINE AND OTHER AGENTS ON ADENYL CYCLASE IN CELL MEMBRANE OF AVIAN ERYTHROCYTES
OYE, I
论文数:
0
引用数:
0
h-index:
0
OYE, I
SUTHERLAND, EW
论文数:
0
引用数:
0
h-index:
0
SUTHERLAND, EW
[J].
BIOCHIMICA ET BIOPHYSICA ACTA,
1966,
127
(02)
: 347
-
+
[27]
Racker E., 1954, GLUTATHIONE, P165
[28]
RODBELL M, 1964, J BIOL CHEM, V239, P375
[29]
PROPERTIES OF AN ADENYL CYCLASE PARTIALLY PURIFIED FROM FROG ERYTHROCYTES
ROSEN, OM
论文数:
0
引用数:
0
h-index:
0
机构:
Departments of Medicine and Molecular Biology, Albert Einstein College of Medicine, Bronx
ROSEN, OM
ROSEN, SM
论文数:
0
引用数:
0
h-index:
0
机构:
Departments of Medicine and Molecular Biology, Albert Einstein College of Medicine, Bronx
ROSEN, SM
[J].
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,
1969,
131
(02)
: 449
-
&
[30]
ROSSMAN T, 1974, J BIOL CHEM, V249, P3412
←
1
2
3
4
→
共 38 条
[21]
CATECHOLAMINE-INDUCED SUBSENSITIVITY OF ADENYLATE CYCLASE ASSOCIATED WITH LOSS OF BETA-ADRENERGIC-RECEPTOR BINDING-SITES
MUKHERJEE, C
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT BIOCHEM,DURHAM,NC
MUKHERJEE, C
CARON, MG
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT BIOCHEM,DURHAM,NC
CARON, MG
LEFKOWITZ, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT BIOCHEM,DURHAM,NC
LEFKOWITZ, RJ
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1975,
72
(05)
: 1945
-
1949
[22]
MUKHERJEE SP, 1978, FED PROC, V37, P1689
[23]
MUKHERJEE SP, 1976, FED PROC, V35, P1694
[24]
REDUCED NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE OXIDASE IN ADIPOCYTE PLASMA-MEMBRANE AND ITS ACTIVATION BY INSULIN - POSSIBLE ROLE IN HORMONES EFFECTS ON ADENYLATE-CYCLASE AND HEXOSE MONOPHOSPHATE SHUNT
MUKHERJEE, SP
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT BIOCHEM,DURHAM,NC 27710
MUKHERJEE, SP
LYNN, WS
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT BIOCHEM,DURHAM,NC 27710
LYNN, WS
[J].
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,
1977,
184
(01)
: 69
-
76
[25]
ENDOGENOUS HYDROGEN-PEROXIDE AND PEROXIDATIVE METABOLISM IN ADIPOCYTES IN RESPONSE TO INSULIN AND SULFHYDRYL-REAGENTS
MUKHERJEE, SP
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
MUKHERJEE, SP
LANE, RH
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
LANE, RH
LYNN, WS
论文数:
0
引用数:
0
h-index:
0
机构:
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
LYNN, WS
[J].
BIOCHEMICAL PHARMACOLOGY,
1978,
27
(22)
: 2589
-
2594
[26]
EFFECT OF EPINEPHRINE AND OTHER AGENTS ON ADENYL CYCLASE IN CELL MEMBRANE OF AVIAN ERYTHROCYTES
OYE, I
论文数:
0
引用数:
0
h-index:
0
OYE, I
SUTHERLAND, EW
论文数:
0
引用数:
0
h-index:
0
SUTHERLAND, EW
[J].
BIOCHIMICA ET BIOPHYSICA ACTA,
1966,
127
(02)
: 347
-
+
[27]
Racker E., 1954, GLUTATHIONE, P165
[28]
RODBELL M, 1964, J BIOL CHEM, V239, P375
[29]
PROPERTIES OF AN ADENYL CYCLASE PARTIALLY PURIFIED FROM FROG ERYTHROCYTES
ROSEN, OM
论文数:
0
引用数:
0
h-index:
0
机构:
Departments of Medicine and Molecular Biology, Albert Einstein College of Medicine, Bronx
ROSEN, OM
ROSEN, SM
论文数:
0
引用数:
0
h-index:
0
机构:
Departments of Medicine and Molecular Biology, Albert Einstein College of Medicine, Bronx
ROSEN, SM
[J].
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,
1969,
131
(02)
: 449
-
&
[30]
ROSSMAN T, 1974, J BIOL CHEM, V249, P3412
←
1
2
3
4
→