QUANTIFICATION OF BINDING TENDENCIES OF CHOLESTYRAMINE .I. EFFECT OF STRUCTURE AND ADDED ELECTROLYTES ON BINDING OF UNCONJUGATED AND CONJUGATED BILE-SALT ANIONS

被引：121

作者：

JOHNS, WH

BATES, TR

机构：

[1] Division of Pharmaceutics, Pharmacy Research Institute, School of Pharmacy, University of Connecticut, Storrs, Connecticut

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 02期

关键词：

Cholestyramine—bile‐salt anion binding; Electrolyte effect—cholestyramine binding; Structure; bile salts—cholestyramine binding; Temperature effect—cholestyramine binding; UV spectrophotometry—analysis;

D O I：

10.1002/jps.2600580206

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The binding of conjugated and unconjugated bile salts to cholestyramine from aqueous media was investigated and the data plotted according to the Langmuir adsorption equation. Higher affinity constants were obtained with the dihydroxy rather than the trihydroxy derivatives. Glycine conjugation was found to alter the affinity constants only slightly, whereas conjugation with taurine markedly increased the affinity of cholestyramine for the bile salt. The addition of bicarbonate or chloride anions to the system produced a significant decrease in the extent of binding of the trihydroxy bile‐salt anions; the effect being more pronounced in the case of the chloride ion. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：179 / &