EFFECTS OF ACTIVATED MACROPHAGES ON MYCOBACTERIUM-LEPRAE

被引：29

作者：

RAMASESH, N ^{[1
]}

ADAMS, LB ^{[1
]}

FRANZBLAU, SG ^{[1
]}

KRAHENBUHL, JL ^{[1
]}

机构：

[1] GILLIS W LONG HANSENS DIS CTR, CARVILLE, LA 70721 USA

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 09期

关键词：

D O I：

10.1128/IAI.59.9.2864-2869.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Five alternative methods were used to explore in vitro the effects of normal and activated murine macrophages on the metabolic well-being of intracellular Mycobacterium leprae: fluorescein diacetate-ethidium bromide staining, ATP content, synthesis of phenolic glycolipid 1, and two techniques to quantitate oxidation of palmitic acid. In relatively short-term experiments (7 to 10 days), each of these procedures provided strong evidence that activated macrophages exerted a deleterious effect on the leprosy bacillus. These findings appear to confirm the contention that activated macrophages underlie host resistance to clinical leprosy and limitation of M. leprae growth in paucibacillary leprosy.

引用

页码：2864 / 2869

页数：6

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