TOTAL SYNTHESIS OF TREHALASE INHIBITOR, TREHAZOLIN

被引：28

作者：

OGAWA, S

UCHIDA, C

机构：

来源：

CHEMISTRY LETTERS | 1993年 / 01期

关键词：

D O I：

10.1246/cl.1993.173

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The total synthesis of trehalase inhibitor, trehazolin has been accomplished by coupling the optically active aminocyclopentanepentaol with alpha-D-glucopyranosylisothiocyanate derivative, followed by subsequent oxazoline-ring formation and removal of the protecting groups, thereby confirming its absolute configuration.

引用

页码：173 / 176

页数：4

共 9 条

[1] TREHAZOLIN, A NEW TREHALASE INHIBITOR [J].

ANDO, O ;

SATAKE, H ;

ITOI, K ;

SATO, A ;

NAKAJIMA, M ;

TAKAHASHI, S ;

HARUYAMA, H ;

OHKUMA, Y ;

KINOSHITA, T ;

ENOKITA, R .

JOURNAL OF ANTIBIOTICS, 1991, 44 (10) :1165-1168

[2]

CAMARASA MJ, 1984, SYNTHESIS-STUTTGART, P509

[3]

KARRER P, 1948, HELV CHIM ACTA, V31, P1617, DOI 10.1002/hlca.19480310623

[4] A NOVEL TREHALASE INHIBITOR, TREHALOSTATIN, PRODUCED BY AMYCOLATOPSIS-TREHALOSTATICA HG-25 [J].

MURAO, S ;

SAKAI, T ;

GIBO, H ;

NAKAYAMA, T ;

SHIN, T .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1991, 55 (03) :895-897

[5]

MURAO S, 1990, 15TH INT CARB S YOK

[6] STRUCTURE OF TREHALOSTATIN - A POTENT AND SPECIFIC INHIBITOR OF TREHALASE [J].

NAKAYAMA, T ;

AMACHI, T ;

MURAO, S ;

SAKAI, T ;

SHIN, T ;

KENNY, PTM ;

IWASHITA, T ;

ZAGORSKI, M ;

KOMURA, H ;

NOMOTO, K .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (14) :919-921

[7] SYNTHESIS OF AMINOCYCLITOL MOIETIES OF TREHALASE INHIBITORS, TREHALOSTATIN AND TREHAZOLIN - CORRECT STRUCTURE OF THE INHIBITOR [J].

OGAWA, S ;

UCHIDA, C ;

YU, YM .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1992, (12) :886-888

[8] SYNTHESIS OF AMINOCYCLITOL MOIETIES OF TREHALASE INHIBITORS, TREHALOSTATIN AND TREHAZOLIN - CONFIRMATION OF THE CORRECT STRUCTURE OF THE INHIBITOR [J].

OGAWA, S ;

UCHIDA, C .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1992, (15) :1939-1942

[9]

TAKAHASHI S, COMMUNICATION

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