GLUCOCORTICOIDS, LIPOCORTINS AND THE IMMUNE-RESPONSE

被引：103

作者：

GOULDING, NJ ^{[1
]}

GUYRE, PM ^{[1
]}

机构：

[1] ST BARTHOLOMEWS HOSP,COLL MED,DEPT RHEUMATOL,LONDON EC1M 6BQ,ENGLAND

来源：

CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 01期

关键词：

D O I：

10.1016/0952-7915(93)90089-B

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Glucocorticoids are immunosuppressive and antiinflammatory agents that act through multiple mechanisms. This review highlights recent evidence that lipocortin-1, a member of the annexin family of calcium-binding proteins, can be induced by glucocorticoids, and may mediate some of the effects of glucocorticoids through putative lipocortin-1 receptors, which have been found on the surface of phagocytic cells. Recent advances in annexin biology have been drawn together to formulate a novel hypothesis for the regulation of inflammation,

引用

页码：108 / 113

页数：6

共 56 条

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