CORRELATION BETWEEN PRECOLONIZATION OF TRIGEMINAL GANGLIA BY ATTENUATED STRAINS OF PSEUDORABIES VIRUS AND RESISTANCE TO WILD-TYPE VIRUS LATENCY

被引:24
作者
SCHANG, LM
KUTISH, GF
OSORIO, FA
机构
[1] UNIV NEBRASKA,INST AGR & NAT RESOURCES,DEPT VET BIOMED SCI,LINCOLN,NE 68583
[2] USDA ARS,PLUM ISL ANIM DIS LAB,GREENPORT,NY 11944
关键词
D O I
10.1128/JVI.68.12.8470-8476.1994
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We compared the levels of latent pseudorabies virus (PRV) DNA in trigeminal ganglia (TG) of pigs after intranasal inoculation of different PRV strains by using quantitative DNA PCR. The extent of colonization attained in each case varied significantly according to the type of strain and inoculum dose, wild-type (WT) PRV being the most efficient strain in colonizing TG. When groups of pigs representing different levels of precolonization of TG with an attenuated PRV strain were challenged with WT PRV, it became evident that there is a statistically significant inverse correlation between the extent of precolonization attained by an attenuated PRV strain in TG and the level of establishment of latency by superinfecting WT PRV. The protection against WT PRV latency did not correlate with the extent of CVT PRV replication at the portal of entry.
引用
收藏
页码:8470 / 8476
页数:7
相关论文
共 35 条
[1]  
BENPORAT T, 1985, HERPESVIRUSES, V3, P105
[2]   PSEUDORABIES VIRUS ENVELOPE GLYCOPROTEIN-GI INFLUENCES BOTH NEUROTROPISM AND VIRULENCE DURING INFECTION OF THE RAT VISUAL-SYSTEM [J].
CARD, JP ;
WHEALY, ME ;
ROBBINS, AK ;
ENQUIST, LW .
JOURNAL OF VIROLOGY, 1992, 66 (05) :3032-3041
[3]   INITIAL HERPES-SIMPLEX VIRUS TYPE-1 INFECTION PREVENTS GANGLIONIC SUPER-INFECTION BY OTHER STRAINS [J].
CENTIFANTOFITZGERALD, YM ;
VARNELL, ED ;
KAUFMAN, HE .
INFECTION AND IMMUNITY, 1982, 35 (03) :1125-1132
[4]   VIRAL, NEURONAL AND IMMUNE FACTORS WHICH MAY INFLUENCE HERPES-SIMPLEX VIRUS (HSV) LATENCY AND REACTIVATION [J].
FRASER, NW ;
VALYINAGY, T .
MICROBIAL PATHOGENESIS, 1993, 15 (02) :83-91
[5]  
GALEOTAWHEELER J, 1991, AM J VET RES, V52, P1799
[6]  
Hill H. T., 1977, Proceedings of the American Association of Veterinary Laboratory Diagnosticians, V20, P375
[7]   HERPES-SIMPLEX VIRUS THYMIDINE KINASE AND SPECIFIC STAGES OF LATENCY IN MURINE TRIGEMINAL GANGLIA [J].
JACOBSON, JG ;
RUFFNER, KL ;
KOSZVNENCHAK, M ;
HWANG, CBC ;
WOBBE, KK ;
KNIPE, DM ;
COEN, DM .
JOURNAL OF VIROLOGY, 1993, 67 (11) :6903-6908
[8]   PATHOGENESIS OF HERPES-SIMPLEX VIRUS IN B-CELL-SUPPRESSED MICE - THE RELATIVE ROLES OF CELL-MEDIATED AND HUMORAL IMMUNITY [J].
KAPOOR, AK ;
NASH, AA ;
WILDY, P .
JOURNAL OF GENERAL VIROLOGY, 1982, 61 (JUL) :127-131
[9]  
KLEIN RJ, 1978, ARCH VIROL, V57, P161, DOI 10.1007/BF01315677
[10]   THE PATHOGENESIS OF ACUTE, LATENT AND RECURRENT HERPES-SIMPLEX VIRUS-INFECTIONS [J].
KLEIN, RJ .
ARCHIVES OF VIROLOGY, 1982, 72 (03) :143-168