CYTOKINES IN T-CELL DEVELOPMENT

被引：187

作者：

CARDING, SR

HAYDAY, AC

BOTTOMLY, K

机构：

[1] YALE UNIV, DEPT ANASTHESIOL, NEW HAVEN, CT 06520 USA

[2] YALE UNIV, SCH MED, IMMUNOBIOL SECT, NEW HAVEN, CT 06510 USA

[3] YALE UNIV, SCH MED, HOWARD HUGHES MED INST, NEW HAVEN, CT 06510 USA

来源：

IMMUNOLOGY TODAY | 1991年 / 12卷 / 07期

关键词：

D O I：

10.1016/0167-5699(91)90037-T

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The thymus provides a unique environment for the development of T cells, supporting both precursor cell proliferation and differentiation. The control of these processes is unknown but they may be mediated by cytokines, or other soluble factors, or by interactions with specific elements of the thymic stroma. Here, Simon Carding, Adrian Hayday and Kim Bottomly describe cellular, immunochemical and molecular studies of the production and action of cytokines within the human and mouse thymus and demonstrate their essential role in T-cell development.

引用

页码：239 / 245

页数：7

共 97 条

[1] A ROLE FOR INTERLEUKIN-4 IN THE DIFFERENTIATION OF MATURE T-CELL RECEPTOR-GAMMA-DELTA+ CELLS FROM HUMAN INTRATHYMIC T-CELL PRECURSORS [J].