PERIPHERAL EDEMA DUE TO INCREASED VASCULAR-PERMEABILITY - A CLINICAL APPRAISAL

被引:11
作者
AGOSTONI, A
CICARDI, M
PORRECA, W
机构
[1] Institute of Internal Medicine, University of Milan, Milan, I-20122
关键词
ANGIOEDEMA; INCREASED VASCULAR PERMEABILITY; VASOACTIVE MEDIATORS;
D O I
10.1007/BF02591654
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The release of vasoactive substances produces reversible changes of endothelial permeability with consequent edematous syndromes. We present 899 patients referred to our clinic for "non-hydrostatic non-hyponcotic" recurrent edema problems. Personal and family histories were recorded and a complete physical examination was carried out for each patient. In chronic situations laboratory tests [blood cell count, cryoglobulins, thyroid hormones, complement components (C3, C4, C1 inhibitor), total IgE, skin testing] were performed. Four subgroups of angioedema are identified for relevant clinical and etiopathogenetic differences. Seventy-three percent of patients had an urticaria-angioedema syndrome responding to antihistamine and/or corticosteroid treatment (histamine-dependent angioedema). Twenty-three percent had an angioedema related to a deficiency in C1 esterase inhibitor (complement-dependent angioedema). In a minority of patients, angioedema was due to the pharmacological effect of a drug (pharmacological angioedema) or was of a totally unknown origin (idiopathic angioedema). A generalized increase in vascular permeability was reported in 3 patients (systemic capillary leak syndrome). A brief survey of the literature is given with the review of our patients.
引用
收藏
页码:241 / 246
页数:6
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