Therapy-related acute promyelocytic leukemia with t(15;17) (q22;q12) following chemotherapy with drugs targeting DNA topoisomerase .2. A report of two cases and a review of the literature

被引:46
作者
Hoffmann, L
Moller, P
PedersenBjergaard, J
Waage, A
Pedersen, M
Hirsch, FR
机构
[1] RIGSHOSP,CANC GENET LAB,DK-2100 COPENHAGEN 0,DENMARK
[2] RIGSHOSP,CYTOGENET SECT 5702,DK-2100 COPENHAGEN 0,DENMARK
[3] RIGSHOSP,SECT HEMATOL L4132,DK-2100 COPENHAGEN 0,DENMARK
[4] RIGSHOSP,FINSEN CTR,DK-2100 COPENHAGEN 0,DENMARK
[5] NORWEGIAN RADIUM HOSP,UNIT MED GENET,TRONDHEIM,NORWAY
[6] REG SJYKEHUSET,DEPT HEMATOL,TRONDHEIM,NORWAY
[7] BISPEBJERG HOSP,DEPT ONCOL,DK-2400 COPENHAGEN,DENMARK
关键词
acute promyelocytic leukemia; t(15; 17); PML-RAR alpha rearrangements; DNA topoisomerase II targeting agents; secondary leukemia;
D O I
10.1093/oxfordjournals.annonc.a059316
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The development of therapy-related acute myeloid leukemia (t-AML) with balanced translocations to chromosome bands 11q23 and 21q22 has recently been significantly related to previous treatment with several cytostatic drugs poisoning DNA topoisomerase II. A similar association was suspected for other balanced chromosomal aberrations such as the t(15;17) characteristic of acute promyelocytic leukemia (APL). Patients and methods: Two cases of acute promyelocytic leukemia were observed following treatment for seminoma with etoposide, cisplatin, and bleomycin and treatment for breast cancer with 4-epi-doxorubicin and subsequent cyclophosphamide, methotrexate, and 5-fluorouracil followed by radiotherapy. Both cases presented a t(15;17) (q22;q12) and were examined for the characteristic chimeric rearrangement of the RAR alpha and PML genes observed in acute promyelocytic leukemia de-novo. Results: In both cases the characteristic chimeric rearrangement was demonstrated. Case no. 2 in addition to the t(15;17) showed an inversion of the long arm of a chromosome no. 5 and a de1(7)(q22) in all abnormal mitoses studied. Despite these findings the patient obtained a complete morphological and cytogenetic remission of the leukemia following treatment with all-trans-retinoic acid. Conclusions: Based on these two cases and a review of the literature it is concluded that the development of t-APL with the balanced translocation t(15;17> is related to previous treatment with cytostatic drugs targeting DNA topoisomerase II and that additional abnormalities of the long arms of chromosomes no. 5 and no. 7 do not interfere with the induction of remission with all- trans-retinoic acid.
引用
收藏
页码:781 / 788
页数:8
相关论文
共 35 条
[31]   THERAPY-RELATED MYELODYSPLASTIC SYNDROMES [J].
ROSENBLOOM, B ;
SCHRECK, R ;
KOEFFLER, HP .
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 1992, 6 (03) :707-722
[32]   15/17 CHROMOSOME-TRANSLOCATION IN ACUTE PROMYELOCYTIC LEUKEMIA [J].
SHEER, D ;
SOLOMON, E ;
GREAVES, MF ;
LISTER, TA .
CANCER GENETICS AND CYTOGENETICS, 1982, 5 (04) :353-354
[33]  
SUPER HJG, 1993, BLOOD, V82, P3705
[34]  
WHANGPENG J, 1988, BLOOD, V71, P403
[35]  
1984, CANCER GENET CYTOGEN, V12, P95