BRAZILIAN PURPURIC FEVER - EVOLUTIONARY GENETIC-RELATIONSHIPS OF THE CASE CLONE OF HEMOPHILUS-INFLUENZAE BIOGROUP AEGYPTIUS TO ENCAPSULATED STRAINS OF HEMOPHILUS-INFLUENZAE

被引：23

作者：

MUSSER, JM ^{[1
]}

SELANDER, RK ^{[1
]}

机构：

[1] PENN STATE UNIV,MUELLER LAB,DEPT BIOL,UNIVERSITY PK,PA 16802

来源：

JOURNAL OF INFECTIOUS DISEASES | 1990年 / 161卷 / 01期

关键词：

D O I：

10.1093/infdis/161.1.130

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

As a first step toward identifying the evolutionary origin of a pathogenic clone of Haemophilus influenzae biogroup aegyptius causing Brazilian purpuric fever, chromosomal variation and genetic relationships were indexed among 17isolates ofbiogroup aegyptius and 2209 previously characterized encapsulated H. influenzae strains recoveredfrom 30 countries on six continents. Biogroup aegyptius isolates form three distinct evolutionary lineages of the species H. inftuenzae and isolates of the case clone are genetically not closely related to other isolates classified as biogroup aegyptius. The Brazilian purpuric fever case clone was found to be genetically allied with H. infiuenzae isolates producing serotype c polysaccharide capsule. The population genetic evidence suggests that biogroup aegyptius isolates may represent cell lineages occasionally transmitted from nonhuman hosts or spawned from a much larger base population consisting of genetically diverse nonpathogenic precursor clones. © 1990 by The University of Chicago. All rights reserved.

引用

页码：130 / 133

页数：4

共 18 条

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[12]

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MUSSER, JM ;

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[16] METHODS OF MULTILOCUS ENZYME ELECTROPHORESIS FOR BACTERIAL POPULATION-GENETICS AND SYSTEMATICS [J].

SELANDER, RK ;

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[17]

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[18]

1985, MMWR, V34, P217

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