BEHAVIORS OF RATS WITH INSIDIOUS, MULTIFOCAL BRAIN-DAMAGE INDUCED BY SEIZURES FOLLOWING SINGLE PERIPHERAL INJECTIONS OF LITHIUM AND PILOCARPINE

被引：78

作者：

PERSINGER, MA ^{[1
]}

BUREAU, YRJ ^{[1
]}

KOSTAKOS, M ^{[1
]}

PEREDERY, O ^{[1
]}

FALTER, H ^{[1
]}

机构：

[1] LAURENTIAN UNIV,BIOCHEM PROGRAM,SUDBURY P3E 2C6,ONTARIO,CANADA

来源：

PHYSIOLOGY & BEHAVIOR | 1993年 / 53卷 / 05期

关键词：

RADIAL ARM MAZE (RAM); CONDITIONED TASTE AVERSION (CTA); LITHIUM; LIMBIC SEIZURE; MEMORY; ACETYLCHOLINE; BRAIN DAMAGE;

D O I：

10.1016/0031-9384(93)90261-D

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Several domains of behavior were measured in rats (n = 465) 10 days to 100 days after induction of limbic seizures by a single subcutaneous injection of lithium and pilocarpine. These rats displayed enhanced intragroup aggression but normal muricide; gustatory neophobia and conditioned taste aversion were virtually eliminated. Severe working and reference memory deficits were evident within the radial arm maze. Both state-dependent memory and possible situation-dependent precipitation of spontaneous seizures were suggested. The behavioral changes were considered commensurate with the multifocal pattern of thalamic, hippocampal/amygdaloid, and limbic cortical damage.

引用

页码：849 / 866

页数：18

共 48 条

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