DETERMINATION OF THE ACTIVE CONFORMATION OF 6-AMINO-ALPHA-[(4-DIPHENYLMETHYL-1-PIPERAZINYL)METHYL-9H-PURINE]-9-ETHANOL - A POSITIVE INOTROPIC AGENT

被引：4

作者：

MILTZ, W

ZIERHUT, W

BUCCHERI, E

SCHULTZ, R

STIRNIMANN, R

机构：

[1] Sandoz Pharma Ltd., Preclinical Research

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80322-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Conformationally restricted analogues of the positive inotropic agent 1 have been synthesized in order to determine its biologically active conformation. Comparison of the distance maps (as a tool for the allowed conformations) with the biological activity give new insights in the biologically active conformation of this class of positive inotropic agents.

引用

页码：1233 / 1239

页数：7

共 13 条

[1] THE ROLE OF SODIUM-CHANNELS IN THE EFFECTS OF THE CARDIOTONIC COMPOUND DPI 201-106 ON CONTRACTILITY AND MEMBRANE-POTENTIALS IN ISOLATED MAMMALIAN HEART PREPARATIONS [J].