NEUROTOXIC DESTRUCTION OF THE SEROTONINERGIC INNERVATION OF THE RAT SUB-COMMISSURAL ORGAN IS FOLLOWED BY RE-INNERVATION THROUGH COLLATERAL SPROUTING OF NON-MONOAMINERGIC NEURONS

被引:29
作者
WIKLUND, L [1 ]
MOLLGARD, K [1 ]
机构
[1] UNIV COPENHAGEN,DEPT ANAT A,DK-2100 COPENHAGEN O,DENMARK
来源
JOURNAL OF NEUROCYTOLOGY | 1979年 / 8卷 / 04期
关键词
D O I
10.1007/BF01214803
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Specific neurotoxic destraction of the serotoninergic innervation of the subcommissural organ of the rat is followed by an efficient reinnervation by collateral sprouting of non-monoaminergic axons, which normally do not innervate the SCO cells. Morphologically, the reinnervating fibres totally replace the serotoninergic synapses lost by the lesion, but, functionally, they fail to substitute for the potent inhibitory control of secretory activity normally exerted by the serotoninergic innervation. It is possible that the observed reinnervation by foreign synapses explains why the regrowing serotoninergic neurons fail to re-establish their connections with the SCO. © 1979 Chapman and Hall Ltd.
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页码:469 / 480
页数:12
相关论文
共 30 条
[21]   INTRACISTERNAL NEUROTOXINS AND MONOAMINE NEURONS INNERVATING SPINAL-CORD - ACUTE AND CHRONIC EFFECTS ON CELL AND AXON COUNTS AND NERVE-TERMINAL DENSITIES [J].
NYGREN, LG ;
OLSON, L .
HISTOCHEMISTRY, 1977, 52 (04) :281-306
[22]   FUNCTIONAL REGENERATION OF 5-HYDROXYTRYPTAMINE NERVE-TERMINALS IN RAT SPINAL-CORD FOLLOWING 5,6-DIHYDROXYTRYPTAMINE INDUCED DEGENERATION [J].
NYGREN, LG ;
FUXE, K ;
JONSSON, G ;
OLSON, L .
BRAIN RESEARCH, 1974, 78 (03) :377-394
[23]   QUANTITATIVE COMPARISON OF FORMATION OF SYNAPSES IN RAT SUPERIOR CERVICAL SYMPATHETIC-GANGLION BY ITS OWN AND BY FOREIGN NERVE-FIBERS [J].
OSTBERG, AJC ;
RAISMAN, G ;
FIELD, PM ;
IVERSEN, LL ;
ZIGMOND, RE .
BRAIN RESEARCH, 1976, 107 (03) :445-470
[24]   QUANTITATIVE INVESTIGATION OF DEVELOPMENT OF COLLATERAL REINNERVATION AFTER PARTIAL DEAFFERENTATION OF SEPTAL NUCLEI [J].
RAISMAN, G ;
FIELD, PM .
BRAIN RESEARCH, 1973, 50 (02) :241-264
[25]   NEURONAL PLASTICITY IN SEPTAL NUCLEI OF ADULT RAT [J].
RAISMAN, G .
BRAIN RESEARCH, 1969, 14 (01) :25-+
[26]   GROWTH OF INTACT CENTRAL ADRENERGIC AXONS IN DENERVATED LATERAL GENICULATE BODY [J].
STENEVI, U ;
BJORKLUND, A ;
MOORE, RY .
EXPERIMENTAL NEUROLOGY, 1972, 35 (02) :290-+
[27]  
SVENDGAARD NA, 1975, ADV ANAT EMBRYOL CEL, V51, P1
[28]  
TSUKAHARA N, 1975, J NEUROPHYSIOL, V38, P1359, DOI 10.1152/jn.1975.38.6.1359
[29]  
Wiklund L, 1978, Ann N Y Acad Sci, V305, P370, DOI 10.1111/j.1749-6632.1978.tb31534.x
[30]  
WINDLE WF, 1955, REGENERATION CENTRAL