MEROZOITE SURFACE ANTIGEN-I OF PLASMODIUM

被引：88

作者：

COOPER, JA

机构：

[1] Zentrum für Molekulare Biologie, Universität Heidelberg, 6900 Heidelberg

来源：

PARASITOLOGY TODAY | 1993年 / 9卷 / 02期

关键词：

D O I：

10.1016/0169-4758(93)90031-A

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The merozoite is the invasive form of the asexual stage of Plasmodium species. At least two polymorphic glycoproteins have been found on its surface in the human malaria parasite Plasmodium falciparum. The best-characterized of these is known as merozoite surface antigen-1 (MSA1) (185-200 kDa) (Ref. 1). Similar molecules are found in other malaria species. The other merozoite surface antigen, MSA2 (35-48 kDa) (Ref. 2), is distinct from MSA1 but is equally polymorphic. In this review, Juan Cooper condenses the body of structural information on MSA1 known to date. A database compiled from MSA1 sequences from several species used together with sequence comparisons and predicted secondary structure reveals interesting features of this molecule.

引用

页码：50 / 54

页数：5

共 42 条

[1]

BANISTER LH, 1990, BLOOD CELLS, V16, P257

[2] SECONDARY PROCESSING OF THE PLASMODIUM-FALCIPARUM MEROZOITE SURFACE PROTEIN-1 (MSP1) BY A CALCIUM-DEPENDENT MEMBRANE-BOUND SERINE PROTEASE - SHEDDING OF MSP133 AS A NONCOVALENTLY ASSOCIATED COMPLEX WITH OTHER FRAGMENTS OF THE MSP1 [J].