INVESTIGATION OF THE DYNAMICS OF CYCLODEXTRINS AND THEIR INCLUSION COMPLEXES IN WATER BY DEUTERIUM NMR

Deuterium NMR and relaxation data are presented to investigate the state of beta-cyclodextrin in aqueous solution rind to derive dynamic parameters for inclusion complexes. Labelled host and guest molecules were used, and dedicated pulse seqnences rue proposed for improving the deuterium spectre in terms of reduction of artifacts and of solvent peak(s) end else in terms of total duration of the experiments. This technique His used to investigate the state of of beta-cyclodextrin in aqueous solution and to derive important information regarding the degree of dynamic coupling between host and guest in inclusion complexes.