IBOPAMINE IN THE TREATMENT OF MILD CHRONIC HEART-FAILURE IN ELDERLY PATIENTS - A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY

被引：6

作者：

AZZOLINI, A

GUFFANTI, E

RONZITTI, M

TANTALO, L

COLANTONI, A

PIZZORNI, C

机构：

[1] UNIV GENOA,PROFESSORIAL DEPT MED PATHOL,I-16126 GENOA,ITALY

[2] INST NAZL RIC & CURA ANZIANI,DEPT CARDIOL,CASATENOVO,ITALY

[3] GERIATR HOSP A DORIA,GENOA,ITALY

[4] GEN HOSP MATERA,DEPT CARDIOL,MATERA,ITALY

[5] ZAMBON GRP SPA,DEPT BIOSTAT,BRESSO,ITALY

来源：

CARDIOLOGY | 1990年 / 77卷

关键词：

Chronic; Elderly; heart failure;

D O I：

10.1159/000174702

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This double-blind, randomized, multicentcr clinical study assessed the efficacy and safety of ibopamine 100 mg t.i.d. as monotherapy vs. placebo in 52 patients with mild chronic heart failure aged over 60 years during a 12-weektreatment period. Ibopamine produced a statistically significant increase in exercise tolerance and reduction in fatigue during effort compared to placebo. A trend towards decreased requirement of concomitant diuretic therapy was noted in the ibopaminc-treated group. Ibopamine was well tolerated throughout the study. This study indicated that ibopamine is an effective and safe agent as monotherapy in the treatment of mild chronic heart failure in elderly patients. © 1990 Karger AG, Basel.

引用

页码：89 / 95

页数：7

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