ELECTROSPRAY INTERFACING FOR THE COUPLING OF ION-EXCHANGE AND ION-PAIRING CHROMATOGRAPHY TO MASS-SPECTROMETRY

被引：40

作者：

SIU, KWM

GUEVREMONT, R

LEBLANC, JCY

GARDNER, GJ

BERMAN, SS

机构：

[1] Institute for Environmental Chemistry, National Research Council of Canada, Ottawa, Ont. K1A 0R9, Montreal Road

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 554卷 / 1-2期

关键词：

D O I：

10.1016/S0021-9673(01)88434-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Electrospray was evaluated as an interface for coupling ion-exchange and ion-pairing chromatography to mass spectrometry. Effective separation and good sensitivity were demonstrated for a liquid flow-rate as high as 50-mu-l/min and a matrix ion concentration as high as 10 mM. Minimum detectable amounts were estimated to be five to ten times poorer than those obtained in the absence of ion-exchange buffers or ion-pairing reagents. The minimum detectable amount for arsenobetaine after a dynamic ion-exchange separation was estimated to be about 20 pg.

引用

页码：27 / 38

页数：12

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