BIOPHARMACEUTICAL STUDIES OF FATTY SUSPENSION SUPPOSITORIES .3. INFLUENCE OF PARTICLE-SIZE AND CONCENTRATION ON BIOAVAILABILITY OF LITHIUM-SULFATE IN RATS

被引：3

作者：

RUTTENKINGMA, JJ ^{[1
]}

DEBLAEY, CJ ^{[1
]}

POLDERMAN, J ^{[1
]}

机构：

[1] UNIV LEIDEN,SUBFAC PHARM,DEPT PHARMACEUT,GORLAEUS LABS,NL-2300 RA,NETHERLANDS

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1979年 / 3卷 / 4-5期

关键词：

D O I：

10.1016/0378-5173(79)90002-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of particle size and concentration of lithium sulphate on the bioavailability in rats is reported. Particles <10 μm exhibit a retardation in absorption as compared with larger ones (45-55 jum, 90-125 μm and 500-630 μm). This is more evident in suppositories containing 20% of the compound than in suppositories containing 5 and 10%, respectively. The results fit a model in which the transport of suspended particles in the suppository vehicle towards the interface with the rectal fluid is rate-limiting. It is therefore suggested to set a lower limit for particles in suspension suppositories, especially for readily water-soluble, hydrophilic, drugs. © 1979.

引用

页码：187 / 194

页数：8

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