SPECIFIC CLEAVAGE OF DNA AT CG SITES BY CO(III) AND NI(II) DESFERAL COMPLEXES

被引：9

作者：

JOSHI, RR ^{[1
]}

GANESH, KN ^{[1
]}

机构：

[1] NATL CHEM LAB,DIV ORGAN CHEM,BIOORGAN CHEM UNIT,POONA 411008,MAHARASHTRA,INDIA

来源：

FEBS LETTERS | 1992年 / 313卷 / 03期

关键词：

DESFERAL; DNA CLEAVAGE; SEQUENCE SPECIFICITY;

D O I：

10.1016/0014-5793(92)81215-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is demonstrated that Co(III) and Ni(II) complexes of desferal, a siderophore chelating drug. show SpeCifiCity for cleavage of DNA at CG sites, while the corresponding Cu(II) complex cleaves DNA sequences at both CG and AT sites.

引用

页码：303 / 306

页数：4

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