GAP-JUNCTION PROTEIN GENE SUPPRESSES TUMORIGENICITY

被引:168
作者
ROSE, B
MEHTA, P
LOEWENSTEIN, WR
机构
[1] Universityof Miami School of Medicine, Department of Physiology and Biophysics, Miami
关键词
D O I
10.1093/carcin/14.5.1073
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Prompted by the notion that the membrane channels in gap junctions conduct growth-regulating signals from cell to cell, we transferred the alpha1 gene for the channel protein (connexin43) of rat heart to tumorigenic mouse MCA-10 cells. Upon incorporation into the cell genome, this exogenous gene was expressed, resulting in functional channels and normal growth regulation: cell-cell communication, determined with a channel-permeant 400-dalton fluorescent tracer, was increased and tumorigenicity, determined in nude mice, was suppressed.
引用
收藏
页码:1073 / 1075
页数:3
相关论文
共 20 条
[11]   TRANSCRIPTIONAL DOWN-REGULATION OF GAP-JUNCTION PROTEINS BLOCKS JUNCTIONAL COMMUNICATION IN HUMAN MAMMARY-TUMOR CELL-LINES [J].
LEE, SW ;
TOMASETTO, C ;
PAUL, D ;
KEYOMARSI, K ;
SAGER, R .
JOURNAL OF CELL BIOLOGY, 1992, 118 (05) :1213-1221
[12]   PERMEABILITY OF MEMBRANE JUNCTIONS [J].
LOEWENST.WR .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1966, 137 (A2) :441-+
[13]  
Loewenstein W R, 1992, Semin Cell Biol, V3, P59
[14]   JUNCTIONAL INTER-CELLULAR COMMUNICATION - THE CELL-TO-CELL MEMBRANE CHANNEL [J].
LOEWENSTEIN, WR .
PHYSIOLOGICAL REVIEWS, 1981, 61 (04) :829-913
[15]   THE CELL-TO-CELL CHANNEL OF GAP-JUNCTIONS [J].
LOEWENSTEIN, WR .
CELL, 1987, 48 (05) :725-726
[16]   GROWTH-INHIBITION OF TRANSFORMED-CELLS CORRELATES WITH THEIR JUNCTIONAL COMMUNICATION WITH NORMAL-CELLS [J].
MEHTA, PP ;
BERTRAM, JS ;
LOEWENSTEIN, WR .
CELL, 1986, 44 (01) :187-196
[17]   INCORPORATION OF THE GENE FOR A CELL-CELL CHANNEL PROTEIN INTO TRANSFORMED-CELLS LEADS TO NORMALIZATION OF GROWTH [J].
MEHTA, PP ;
HOTZWAGENBLATT, A ;
ROSE, B ;
SHALLOWAY, D ;
LOEWENSTEIN, WR .
JOURNAL OF MEMBRANE BIOLOGY, 1991, 124 (03) :207-225
[18]   TUMOR SUPPRESSOR GENES - THE PUZZLE AND THE PROMISE [J].
SAGER, R .
SCIENCE, 1989, 246 (4936) :1406-1412
[19]   EXPRESSION OF CX26, CX32 AND CX43 GAP JUNCTION PROTEINS IN NORMAL AND NEOPLASTIC HUMAN TISSUES [J].
WILGENBUS, KK ;
KIRKPATRICK, CJ ;
KNUECHEL, R ;
WILLECKE, K ;
TRAUB, O .
INTERNATIONAL JOURNAL OF CANCER, 1992, 51 (04) :522-529
[20]  
WILLECKE K, 1990, EUR J CELL BIOL, V53, P275