CELLULAR MECHANISMS OF SOMATOSTATIN ACTION IN THE GUT

被引：10

作者：

DELVALLE, J ^{[1
]}

PARK, J ^{[1
]}

CHIBA, T ^{[1
]}

YAMADA, T ^{[1
]}

机构：

[1] KOBE UNIV,SCH MED,DEPT INTERNAL MED 3,KOBE 650,JAPAN

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1990年 / 39卷 / 09期

关键词：

D O I：

10.1016/0026-0495(90)90231-Z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have used isolated canine parietal cells to examine the receptor and postreceptor events mediating the inhibitory effects of somatostatin on acid secretion. Somatostatin-14 (S14) and somatostatin-28 (S28) dose dependently inhibited parietal cells stimulated by secretagogues that activate both the adenylate cyclase/cyclic adenosine monophosphate and the inositol phospholipid/protein kinase C cascades. The inhibitory action was mediated via a specific cell surface receptor that consists of a single subunit protein (molecular weight 99,000 d). This receptor recognized S14 and S28 equally well. Somatostatin inhibited parietal cell activity via mechanisms that are both dependent on and independent of a pertussis toxin-sensitive inhibitory guanine nucleotide binding protein. © 1990.

引用

页码：134 / 137

页数：4

共 22 条

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