POLYDISCAMIDE-A - A NEW BIOACTIVE DEPSIPEPTIDE FROM THE MARINE SPONGE DISCODERMIA SP

被引：65

作者：

GULAVITA, NK ^{[1
]}

GUNASEKERA, SP ^{[1
]}

POMPONI, SA ^{[1
]}

ROBINSON, EV ^{[1
]}

机构：

[1] HARBOR BRANCH OCEANOG INST INC,DIV BIOMED MARINE RES,5600 OLD DIXIE HIGHWAY,FT PIERCE,FL 34946

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 06期

关键词：

D O I：

10.1021/jo00032a031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A depsipeptide, polydiscamide A (1), composed of 13 amino acids including a novel amino acid 3-methylisoleucine, was isolated from a Caribbean sponge, Discodermia sp. Its structure was elucidated by means of spectroscopic, chemical degradation, and derivatization techniques. Polydiscamide A inhibits the in vitro proliferation of the cultured human lung cancer A549 cell line.

引用

页码：1767 / 1772

页数：6

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