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SIMULTANEOUS NONINVASIVE EVALUATION OF GASTRIC-EMPTYING AND OROCECAL TRANSIT TIMES - USE IN STUDYING THE ACTIONS OF CISAPRIDE IN DIABETIC-PATIENTS

被引：7
作者：
BERGMANN, JF
CHASSANY, O
GUILLAUSSEAU, PJ
BAYLE, M
CHAGNON, S
CAULIN, C
SALLENAVE, JR
机构：
[1] HOP LARIBOISIERE, DEPT ENDOCRINOL, F-75475 PARIS 10, FRANCE
[2] HOP LARIBOISIERE, DEPT PHARM, F-75475 PARIS 10, FRANCE
[3] HOP LARIBOISIERE, DEPT RADIOL, F-75475 PARIS 10, FRANCE
[4] JANSSEN LABS, BOULOGNE, FRANCE
来源：
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 43卷 / 02期
关键词：
CISAPRIDE; DIABETIC NEUROPATHY; GASTRIC EMPTYING; OROCECAL TRANSIT TIME; GASTROPARESIS; CONTROLLED TRIAL;
D O I：
10.1007/BF01740656
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of the study was to use a novel combination of two methods for the simultaneous evaluation of two effects of oral cisapride in 10 diabetic patients with autonomic neuropathy; gastric emptying time was measured by following radio-opaque markers and orocaecal transit time by the sulphasalazine-sulphapridine method. The study was of double-blind, randomized, placebo-controlled, cross-over design. It was possible to evaluate the effect of a prokinetic drug on gastric emptying and orocaecal transit times using these two noninvasive techniques at the same time. Cisapride significantly reduced both the gastric emptying (1.2 h versus 2.1 h) and orocaecal tansit (5.9 h versus 7.7 h) times.
引用
收藏
页码：121 / 124
页数：4
相关论文
共 28 条
[1]   SEGMENTAL COLONIC TRANSIT-TIME [J].
ARHAN, P ;
DEVROEDE, G ;
JEHANNIN, B ;
LANZA, M ;
FAVERDIN, C ;
DORNIC, C ;
PERSOZ, B ;
TETREAULT, L ;
PEREY, B ;
PELLERIN, D .
DISEASES OF THE COLON & RECTUM, 1981, 24 (08) :625-629
[2]  
BERTRAND J, 1980, GASTROEN CLIN BIOL, V4, P770
[3]  
BIGARD MA, 1988, GASTROEN CLIN BIOL, V12, P75
[4]   CISAPRIDE AND GASTRIC-EMPTYING OF A SOLID MEAL IN DYSPEPTIC DIABETICS WITHOUT AUTONOMIC NEUROPATHY AND IN HEALTHY-VOLUNTEERS [J].
BROGNA, A ;
FERRARA, R ;
SCORNAVACCA, G ;
LOMBARDO, A ;
BUCCERI, A ;
CATALANO, F ;
PARADISI, V ;
ONORATO, S .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1989, 37 (04) :411-413
[5]   IMPAIRED GASTRIC-EMPTYING IN DIABETIC-PATIENTS WITH CARDIAC AUTONOMIC NEUROPATHY [J].
BUYSSCHAERT, M ;
MOULART, M ;
URBAIN, JL ;
PAUWELS, S ;
DEROY, L ;
KETELSLEGERS, JM ;
LAMBERT, AE .
DIABETES CARE, 1987, 10 (04) :448-452
[6]   GASTRIC-EMPTYING IN DIABETIC AUTONOMIC NEUROPATHY [J].
CAMPBELL, IW ;
HEADING, RC ;
TOTHILL, P ;
BUIST, TAS ;
EWING, DJ ;
CLARKE, BF .
GUT, 1977, 18 (06) :462-467
[7]  
CHAUSSADE S, 1986, GASTROEN CLIN BIOL, V10, P385
[8]   EFFECT OF CHRONIC ADMINISTRATION OF CISAPRIDE ON GASTRIC-EMPTYING OF A SOLID MEAL AND ON DYSPEPTIC SYMPTOMS IN PATIENTS WITH IDIOPATHIC GASTROPARESIS [J].
CORINALDESI, R ;
STANGHELLINI, V ;
RAITI, C ;
REA, E ;
SALGEMINI, R ;
BARBARA, L .
GUT, 1987, 28 (03) :300-305
[9]   EFFECT OF CISAPRIDE ON THE GASTROINTESTINAL TRANSIT OF A SOLID MEAL IN NORMAL HUMAN-SUBJECTS [J].
EDWARDS, CA ;
HOLDEN, S ;
BROWN, C ;
READ, NW .
GUT, 1987, 28 (01) :13-16
[10]   DIABETIC AUTONOMIC NEUROPATHY - PRESENT INSIGHTS AND FUTURE-PROSPECTS [J].
EWING, DJ ;
CLARKE, BF .
DIABETES CARE, 1986, 9 (06) :648-665
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