SIMULTANEOUS NONINVASIVE EVALUATION OF GASTRIC-EMPTYING AND OROCECAL TRANSIT TIMES - USE IN STUDYING THE ACTIONS OF CISAPRIDE IN DIABETIC-PATIENTS

被引：7

作者：

BERGMANN, JF

CHASSANY, O

GUILLAUSSEAU, PJ

BAYLE, M

CHAGNON, S

CAULIN, C

SALLENAVE, JR

机构：

[1] HOP LARIBOISIERE, DEPT ENDOCRINOL, F-75475 PARIS 10, FRANCE

[2] HOP LARIBOISIERE, DEPT PHARM, F-75475 PARIS 10, FRANCE

[3] HOP LARIBOISIERE, DEPT RADIOL, F-75475 PARIS 10, FRANCE

[4] JANSSEN LABS, BOULOGNE, FRANCE

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 43卷 / 02期

关键词：

CISAPRIDE; DIABETIC NEUROPATHY; GASTRIC EMPTYING; OROCECAL TRANSIT TIME; GASTROPARESIS; CONTROLLED TRIAL;

D O I：

10.1007/BF01740656

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of the study was to use a novel combination of two methods for the simultaneous evaluation of two effects of oral cisapride in 10 diabetic patients with autonomic neuropathy; gastric emptying time was measured by following radio-opaque markers and orocaecal transit time by the sulphasalazine-sulphapridine method. The study was of double-blind, randomized, placebo-controlled, cross-over design. It was possible to evaluate the effect of a prokinetic drug on gastric emptying and orocaecal transit times using these two noninvasive techniques at the same time. Cisapride significantly reduced both the gastric emptying (1.2 h versus 2.1 h) and orocaecal tansit (5.9 h versus 7.7 h) times.

引用

页码：121 / 124

页数：4

共 28 条

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